GLP-1 RAs Linked to Higher Hair Loss Risk
A large matched cohort study quantifies the association between glucagon-like peptide-1 receptor agonist use and nonscarring alopecia
A multicenter cohort study published in JAAD International found that adults utilizing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) face significantly higher odds of nonscarring hair loss after 6 and 12 months compared to matched controls. The research utilized data from the TriNetX US Collaborative Network, examining patients aged 12-89 treated with these medications from 2014-2024. Key findings indicate increases in telogen effluvium and androgenetic alopecia among GLP-1 RA users, suggesting a need for awareness and monitoring amidst potential confounding factors.
1. GLP-1 RAs are linked to increased odds of nonscarring hair loss.2. Study used data from TriNetX US Collaborative Network.3. 1.62 times odds of androgenetic alopecia at 6 months.4. Increased odds for telogen effluvium and overall hair loss by 12 months.5. Study conducted from 2014 to 2024.6. Pediatric data was limited, affecting analysis.7. Monitoring of hair loss risk in patients on GLP-1 RAs is necessary.