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Meat Intake, APOE Status Linked to Cognitive Aging

Long-term cohort data suggest genotype-specific associations with cognition, not dementia interaction

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A cohort study published in JAMA Network Open found that higher total meat consumption is linked to favorable cognitive outcomes among older individuals with specific apolipoprotein E (APOE) genotypes (epsilon 3/epsilon 4 and epsilon 4/epsilon 4). In a sample of over 2,000 patients aged 60 or older, those with the specified genotypes demonstrated slower cognitive decline and lower dementia risk with increased meat intake. However, these associations were not found in patients with other genotypes, indicating a complex relationship between diet and genetics in cognitive health.

Original Source(s)

Meat Intake, APOE Status Linked to Cognitive Aging

  • by Kathryn Wighton

  • March 31, 2026

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