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Why Does Ovarian Cancer Spread So Fast?

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  • February 23, 2026

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Recent research published in Science Advances reveals a significant mechanism by which epithelial ovarian cancer (EOC) spreads aggressively within the abdomen. Ovarian cancer cells in ascites form compact spheroids in which they often aggregate with mesothelial cells, which are typically protective of the abdominal cavity. These clusters are highly invasive, enabling rapid penetration of tissues. The study identifies potential therapeutic targets in disrupting these interactions to reduce EOC metastasis and improve patient outcomes.

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