Why Does Ovarian Cancer Spread So Fast?
New research finds that cancer cells partner the body's own protective cells to drive rapid metastasis
Recent research published in Science Advances reveals a significant mechanism by which epithelial ovarian cancer (EOC) spreads aggressively within the abdomen. Ovarian cancer cells in ascites form compact spheroids in which they often aggregate with mesothelial cells, which are typically protective of the abdominal cavity. These clusters are highly invasive, enabling rapid penetration of tissues. The study identifies potential therapeutic targets in disrupting these interactions to reduce EOC metastasis and improve patient outcomes.
1. EOC cells in ascites exist mainly as compact spheroids. 2. These spheroids often include mesothelial cells. 3. Mesothelial cells aid in cancer tissue invasion. 4. Presence of malignant cells is linked to shorter progression-free survival. 5. Ascites is an active environment promoting metastasis. 6. Potential therapeutic target: disrupt cancer-mesothelial interactions. 7. Evaluate both malignant and nonmalignant cells for disease progression.