Keratoconus (KCN) is a progressive corneal ectasia often diagnosed late due to unpredictable nature and absence of universal screening strategies. A systematic review in Ophthalmology Science highlights the vital role of hormonal fluctuations related to the hypothalamic-pituitary-gonadal axis in KCN onset and progression. The review, spanning over six decades and comprising 26 studies, found hormonal changes, particularly during pregnancy and with congenital abnormalities, significantly linked to KCN. Clinicians are urged to integrate hormonal history into risk assessments for better screening.
1. Keratoconus (KCN) often diagnosed late due to unpredictability.2. Systematic review highlights hormonal influence on KCN progression.3. Study covers data from 1963 to 2025 with 26 key studies.4. Elevated DHEAS linked to KCN onset in numerous reports.5. Hormonal shifts noted during pregnancy and with hormonal therapy as risk factors.6. Authors advocate for enhanced screening protocols based on hormonal history.7. The review suggests systemic components contribute to KCN.
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