From the Journals

Creatinine Index Linked to CKD Mortality

Prospective UK cohort study links higher creatinine muscle index to lower odds of probable sarcopenia and reduced pre–kidney replacement therapy mortality.

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A prospective cohort study involving 2,930 patients with nondialysis chronic kidney disease revealed that a higher creatinine muscle index correlates with lower odds of probable sarcopenia and reduced all-cause mortality prior to kidney replacement therapy. Conducted by Thomas McDonnell, MBChB, from the Donal O’Donoghue Renal Research Centre, the study found significant associations between creatinine muscle index and muscle strength, as well as decreased mortality risk, suggesting its potential as a useful clinical tool in managing kidney disease-related complications.

Original Source(s)

Creatinine Index Linked to CKD Mortality

Prospective UK cohort study links higher creatinine muscle index to lower odds of probable sarcopenia and reduced pre–kidney replacement therapy mortality.

  • by Doug Brunk

  • February 18, 2026

  • 3 min

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