Low DLCO/SB Linked to Faster SSc Progression - Summary - MDSpire
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Low DLCO/SB Linked to Faster SSc Progression

Lower gas transfer at baseline was associated with higher unadjusted progression rates and shorter time to transition, though multivariable analysis did not identify independent predictors

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A retrospective longitudinal study involving 73 patients revealed that lower baseline diffusing capacity of the lungs for carbon monoxide (DLCO/SB) is linked to a higher risk of progressing to systemic sclerosis (SSc) and a quicker transition in individuals with early-stage disease. Over five years, 12% of patients progressed to definite SSc, with notably higher rates among those with DLCO/SB below 70%. Other factors such as SSc-specific antibodies also played a role in progression, but no variable emerged as a significant independent predictor.

Original Source(s)

Low DLCO/SB Linked to Faster SSc Progression

  • by Andrea Surnit

  • April 6, 2026

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