From the Journals

Genetic Variant Ups Heart Failure Risk in Black Americans

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A recent study highlights the impact of the V142I variant of the transthyretin gene on heart failure (HF) and mortality in Black Americans. Carriers of this variant face a significantly higher risk of HF hospitalization by age 63 and all-cause mortality by age 72, contributing to approximately 1 million years of life lost among Black Americans aged 50 years and older. The findings underscore the importance of early identification and treatment of V142I carriers with ATTRv-CA to mitigate the significant public health impact.

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