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Shining a Light into the ADC Conjugation Black Box

A multi-year hunt for a “Goldilocks salt” paved the way for HIC-MS coupling and real-time ADC reaction monitoring

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Hydrophobic interaction chromatography (HIC) has been an essential method for characterizing antibody-drug conjugates (ADCs), yet its use in real-time monitoring has been limited. Researchers from Genentech, led by Bingchuan Wei, have developed a novel approach using ammonium tartrate to maintain HIC performance while allowing compatibility with mass spectrometry. This innovation enables real-time analysis of ADC reactions and enhances understanding of bioconjugation processes. This study illustrates the importance of agile analytical methods in improving efficiency and product quality in pharmaceutical manufacturing.

Original Source(s)

Shining a Light into the ADC Conjugation Black Box

A multi-year hunt for a “Goldilocks salt” paved the way for HIC-MS coupling and real-time ADC reaction monitoring

  • by James Strachan

  • March 5, 2026

  • 9 min

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