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The Baby Steps of Infant Immunity

LC-MS profiling shows rapid establishment of systemic immunity in infants 

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  • March 4, 2026

  • 2 min

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A recent study has revealed that newborns start producing their own antibodies within weeks of birth rather than depending entirely on maternal antibodies. By utilizing intact LC-MS-based Fab profiling, researchers compared IgA1 and IgG1 antibody repertoires from maternal and infant samples. They observed that while maternal IgG1 was predominant at birth, by 7-11 weeks, infants generated new specific IgA1 and IgG1 antibodies, indicating early immune system activation. This challenges previous assumptions about maternal antibody transfer and emphasizes the importance of early neonatal immune development and potential vaccine strategies.

Original Source(s)

The Baby Steps of Infant Immunity

LC-MS profiling shows rapid establishment of systemic immunity in infants 

  • March 4, 2026

  • 2 min

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