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Collagen: Emerging Importance in Dry Eye Therapy 

Advances in corneal science are reshaping how we understand – and potentially treat – dry eye disease

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Collagen, the predominant protein in the human body, plays a crucial role in maintaining corneal integrity and epithelial function. Disruption of collagen in conditions like dry eye disease leads to increased epithelial turnover and inflammation, ultimately compromising corneal barrier function. Collagen mimetic peptides (CMPs) offer a novel therapeutic approach, effectively restoring collagen structure and signaling pathways, thereby enhancing epithelial repair and normalizing tear film stability. Recent clinical trials, including the ST-100 phase 2 trial, demonstrate significant efficacy of CMPs in improving ocular surface integrity and patient comfort in dry eye disease.

Original Source(s)

Collagen: Emerging Importance in Dry Eye Therapy 

Advances in corneal science are reshaping how we understand – and potentially treat – dry eye disease

  • by Jay S. Pepose

  • March 10, 2026

  • 8 min

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