Parasutterella excrementihominis Promotes Experimental Colitis and Colitis-Related Colorectal Cancer Through the Induction of Pathogenic NETosis - Takeaway - MDSpire

Parasutterella excrementihominis Promotes Experimental Colitis and Colitis-Related Colorectal Cancer Through the Induction of Pathogenic NETosis

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  • 1

    Parasutterella excrementihominis is enriched in ulcerative colitis patients and linked to increased disease activity.

  • 2

    P. excrementihominis exacerbates experimental colitis and colorectal cancer by inducing pathogenic NETosis through specific metabolites.

  • 3

    The metabolites succinic acid and 6-hydroxyhexanoic acid activate NETosis via succinate receptor 1 and G protein-coupled receptor 84 signaling.

  • 4

    Dysregulated NETosis contributes to mucosal damage and inflammation in ulcerative colitis and colitis-associated colorectal cancer.

  • 5

    Targeting P. excrementihominis or its metabolites may provide new therapeutic strategies for managing ulcerative colitis and colorectal cancer.

Original Source(s)

Parasutterella excrementihominis Promotes Experimental Colitis and Colitis-Related Colorectal Cancer Through the Induction of Pathogenic NETosis

  • by Huishi Tan, Linwen Huang, Jun Wang, Hongli Huang, Zelong Lin, Siqi Yang, Yanqiang Shi, Jierui Li, Haiyan Zhang, Yongjian Zhou, Chongyang Huang

  • May 1, 2026

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