Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease - Takeaway - MDSpire

Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease

Share

  • 1

    Activation of the pentose phosphate pathway (PPP) in fibroblasts is a key feature of intestinal fibrosis in Crohn's disease.

  • 2

    Xylulokinase (XYLB) generates xylulose-5-phosphate (Xu5P), which promotes collagen synthesis in fibrotic fibroblasts.

  • 3

    CircPLCE1 downregulation in fibroblasts leads to increased PPP activation and collagen production during intestinal fibrogenesis.

  • 4

    CircPLCE1 interacts with XYLB, inhibiting its activity and regulating the PPP and fibrogenesis in intestinal fibrosis.

  • 5

    The circPLCE1/XYLB/Xu5P axis presents a novel therapeutic target for treating intestinal fibrosis in Crohn's disease.

Original Source(s)

Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease

  • by Longyuan Zhou, Jing Nie, Zhiyin Feng, Rongchang Li, Pingxin Zhang, Sinan Lin, Yao Zhang, Florian Rieder, Changhao Chen, Minhu Chen, Ren Mao

  • May 1, 2026

Related Content

Plastic Meets Biomass to Boost Biofuel Yields

Co-pyrolysis study reveals how agricultural waste and LDPE films work together to produce cleaner, energy-rich fuels

  • April 10, 2026

  • 2 min
Molecular Test Doubles Detection of Bile Duct Cancer

According to recent research, a new molecular test could detect bile duct cancer with twice the sensitivity of the standard test, giving physicians a more accurate picture of a patient’s diagnosis. 

New Histology Signal in Crohn’s

Distinct lymphoid structures identified in fibrostenosing Crohn’s specimens

  • March 26, 2026

  • 2 min