Heat stress-mediated oxidative damage in male germ cells: potential protective effects of L-citrulline

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  • 1

    Heat stress significantly impairs male reproductive function by disrupting spermatogenesis and inducing oxidative stress in germ cells.

  • 2

    Oxidative stress leads to excessive reactive oxygen species accumulation, causing damage to lipids, proteins, and DNA in male reproductive cells.

  • 3

    L-citrulline shows potential as a protective agent against heat stress-induced reproductive damage by modulating the arginine-nitric oxide pathway.

  • 4

    L-citrulline preserves mitochondrial function and reduces apoptotic signaling, thereby mitigating oxidative injury in male germ cells.

  • 5

    The review emphasizes the need for translational research on L-citrulline to improve fertility outcomes in men exposed to heat stress.

Original Source(s)

Heat stress-mediated oxidative damage in male germ cells: potential protective effects of L-citrulline

  • by Yan Qin, Hongmei Wu, Linfeng Mo, Huihuang Shen, Yanqing Tan, Weijun Li, Yonghua He, Wei Peng

  • March 20, 2026

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