MDSpire - Takeaway

Association between insulin resistance trajectories and perinatal complications: a retrospective cohort study

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  • 1

    Insulin resistance (IR) during pregnancy can lead to significant perinatal complications, including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP).

  • 2

    The study identified four distinct trajectories of IR changes during pregnancy, categorized as low, moderate, high, and low-high levels.

  • 3

    Moderate and high IR trajectories significantly increased the risk of GDM, with adjusted relative risks of 1.73 and 2.40, respectively.

  • 4

    The low-high IR trajectory, which sharply increased in late pregnancy, showed a notably higher risk for HDP with an adjusted relative risk of 6.45.

  • 5

    Early pregnancy IR values effectively predicted GDM and HDP, with fasting serum insulin demonstrating the highest predictive ability for HDP.

Original Source(s)

Association between insulin resistance trajectories and perinatal complications: a retrospective cohort study

  • by Lisha Ye, Lixia Shen, Shaofeng Zhang, Caixia Zhu, Shiqin Cai, Jingwan Huang, Lepei Xie, Haitian Chen

  • March 30, 2026

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