Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population - Takeaway - MDSpire

Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population

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  • 1

    The study established age- and gender-specific reference intervals for the triglyceride-glucose index in a large cohort of healthy Chinese adults.

  • 2

    A total of 201,623 individuals were screened, with significant nonlinear relationships between the TyG index and age identified.

  • 3

    Stratified reference intervals were defined for males and females aged 18-64 and those aged 65 and older, with overall RI set at 7.47-8.90.

  • 4

    Validation in an independent cohort of 127,143 individuals showed only 4.76% to 5.37% of values fell outside the proposed reference intervals.

  • 5

    The established reference intervals enhance the clinical utility of the TyG index for metabolic risk assessment in healthy populations.

Original Source(s)

Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population

  • by Shanshan Huang, Liming Qin, Chuanfu Lu, Weinan Li, Yibo Wang, Dan He, Yuni Mai, Na Lu, Qiuyu Lu, Shiwei Huang, Xiaowen Zheng, Jianfeng Zhang, Jihua Feng

  • April 16, 2026

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