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1
A 52-year-old man presented with chronic diarrhea and significant weight loss, leading to a BMI of 14.9 kg/m².
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2
Laboratory tests indicated anemia, low serum protein, and elevated IgM and β2-microglobulin levels.
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3
Histological examination revealed marked villous blunting and dilated lymphatic vessels in the terminal ileum.
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4
The diagnosis was Waldenström’s macroglobulinaemia with intestinal lymphangiectasia, confirmed by immunophenotyping and genetic testing.
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5
Treatment with the RCD regimen resulted in improved symptoms and nutritional status, with significant regression of intestinal lesions.
Original Source(s)
Cause of chronic diarrhoea
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by Tingting Cao, Honggang Wang
May 1, 2026
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