Effects of gender-affirming hormone therapy from adolescence to adulthood on cardiovascular function: a cross-sectional study

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  • 1

    The study evaluated cardiovascular function in 47 trans men and 6 trans women who underwent gender-affirming hormone therapy for 5–10 years.

  • 2

    Most cardiovascular parameters were normal, with only one trans man showing grade 2 diastolic dysfunction after long-term hormone therapy.

  • 3

    Gender-affirming hormone therapy was linked to reduced aortic distensibility and increased aortic stiffness in both trans men and women.

  • 4

    The study found no significant cardiac complications related to hypertrophy or chamber dimensions in participants receiving hormone therapy.

  • 5

    Long-term effects of altered aortic elasticity due to hormone therapy remain unclear and warrant further investigation.

Original Source(s)

Effects of gender-affirming hormone therapy from adolescence to adulthood on cardiovascular function: a cross-sectional study

  • by Silvia Ciancia, Simon D’hulst, Jeroen Vervalcke, Daniel Klink, Guy T’Sjoen, Katya De Groote, Martine Cools, Laura Muiño Mosquera

  • March 18, 2026

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