Reply to “Checking the shape of hepatocellular carcinoma: How irregular is irregular?”
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By
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March 21, 2026
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1
The ATSI score combines alpha-fetoprotein levels and tumor shape irregularity for survival prediction in advanced hepatocellular carcinoma patients.
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2
Tumor shape irregularity was defined using four CT/MRI criteria, validated by three senior radiologists to minimize interobserver bias.
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3
AI-based radiomics analysis revealed that 3D shape irregularity correlates significantly with poor prognosis in hepatocellular carcinoma.
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4
The total tumor volume is a more accurate measure of tumor burden than diameter or number-based parameters in HCC prognostic models.
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The ATSI score supports personalized treatment decisions, but its clinical utility needs confirmation through large-scale prospective studies.
