The diagnostic value of immune-inflammatory markers for diabetic kidney disease in type 2 diabetic patients: a meta-analysis
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By
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March 25, 2026
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1
Diabetic kidney disease (DKD) affects up to 40% of individuals with type 2 diabetes and is a leading cause of end-stage renal disease.
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The meta-analysis evaluated immune-inflammatory biomarkers for diagnosing early and established DKD, including PLR, MLR, and SII.
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For early DKD, PLR demonstrated a sensitivity of 0.74 and specificity of 0.69, while SII showed a sensitivity of 0.68 for established DKD.
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Common immune-inflammatory markers exhibit low to moderate diagnostic accuracy for DKD, with PLR and SII being the most promising.
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Future high-quality studies are needed to validate the diagnostic significance of these biomarkers due to limitations in current research.
