FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis - Takeaway - MDSpire

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

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  • 1

    Eosinophilic esophagitis (EoE) is characterized by epithelial remodeling and barrier dysfunction due to T-helper type 2 inflammation.

  • 2

    FOXM1 is identified as a key transcriptional regulator that drives epithelial disruption in EoE.

  • 3

    Inhibition of FOXM1 restores epithelial differentiation, reduces proliferation, and improves barrier integrity in EoE.

  • 4

    Targeting FOXM1 presents a novel therapeutic strategy to enhance epithelial homeostasis and mitigate inflammation in EoE.

  • 5

    This dual approach addressing both epithelial and immune dysregulation may improve patient outcomes in EoE.

Original Source(s)

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

  • by Masaru Sasaki, Joshua X Wang, Ryugo Teranishi, Takefumi Itami, Yusen Zhou, Kanak V Kennedy, Ann Semeao, Satoshi Ishikawa, Takeo Hara, Emily A McMillan, Mark Mahon, Hailey Golden, Diya Dhakal, Alyssa Baccarella, Heidi Winters, Chizoba N Umeweni, Benjamin J Wilkins, Tatiana A Karakasheva, Kelly A Whelan, Sydney M Shaffer, Melanie A Ruffner, Amanda B Muir

  • May 1, 2026

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