MDSpire - Takeaway

Oocyte maturation triggering in high responders in IVF treatment: a systematic review and network meta-analysis

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  • 1

    This study compares the efficacy and safety of four oocyte maturation triggers in high responders during IVF using a network meta-analysis.

  • 2

    Seven high-quality RCTs involving 632 women were included, showing no significant differences in oocyte yield or clinical pregnancy rates among the triggers.

  • 3

    The GnRHa trigger significantly reduced the risk of moderate to severe ovarian hyperstimulation syndrome compared to hCG.

  • 4

    GnRHa, hCG, and dual triggers showed similar efficacy, but GnRHa provided a better safety profile regarding OHSS risk.

  • 5

    Further multicenter RCTs are needed to assess live birth outcomes and the role of the double trigger in high responders.

Original Source(s)

Oocyte maturation triggering in high responders in IVF treatment: a systematic review and network meta-analysis

  • by Yusuf Beebeejaun, Timothy Copeland, James M. N. Duffy, Ippokratis Sarris, Marian Showell, Sesh K. Sunkara

  • April 2, 2026

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