Alcohol consumption exacerbates high-fat diet-mediated disruptions in myelopoiesis and osteoclastogenesis in mouse models of metabolic dysfunction-associated liver diseases

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  • 1

    High-fat diet (HFD) depletes hematopoietic stem cells, while HFD plus ethanol (HFD+EtOH) preserves them and skews hematopoiesis toward myeloid progenitors.

  • 2

    HFD+EtOH significantly increases committed osteoclast precursors compared to HFD alone, enhancing osteoclastogenesis and associated bone activity.

  • 3

    Mice on HFD+EtOH exhibit elevated osteoclast activity, increased epiphyseal area, and prolonged growth plate activity, affecting bone structure.

  • 4

    The study highlights the interplay between metabolic dysfunction-related liver diseases and hematopoietic health, emphasizing the need for integrated treatment approaches.

  • 5

    Findings suggest that alcohol exacerbates the effects of a high-fat diet on immune and skeletal health, warranting further research into these interactions.

Original Source(s)

Alcohol consumption exacerbates high-fat diet-mediated disruptions in myelopoiesis and osteoclastogenesis in mouse models of metabolic dysfunction-associated liver diseases

  • by Hami Hemati, Madison B. Blanton, Lauren Rutt, Nicholas Keiran, Rebecca Geron, Florence Lima, Rebecca L. McCullough, Ilhem Messaoudi

  • March 20, 2026

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