ATM IHC Identifies POLE-Mutant Endometrial Cancer - Takeaway - MDSpire
From the Journals

ATM IHC Identifies POLE-Mutant Endometrial Cancer

Loss staining patterns help flag tumors for sequencing when molecular testing is limited.

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  • 1

    ATM IHC identifies endometrial cancer patients with POLE variants.

  • 2

    Achieved 97% specificity and 80% accuracy in detections.

  • 3

    Patients with POLE variants exhibited nondiffuse ATM staining.

  • 4

    Null staining patterns observed only in tumors with pathogenic mutations.

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    Study limited by single-center design and sample size.

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    Suggests cost-effective screening for molecular testing based on ATM staining.

Original Source(s)

ATM IHC Identifies POLE-Mutant Endometrial Cancer

  • by Andrea Surnit

  • April 2, 2026

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