From the Journals

Weight Regain Rapidly Follows GLP-1 Cessation

Systematic review finds most lost weight returns within two years of stopping weight management medication

Share

  • 1

    Weight regain after ceasing weight management medications is rapid.

  • 2

    Average loss during treatment: 8.3 kg.

  • 3

    Patients regain ~0.4 kg/month post-treatment.

  • 4

    Baseline weight returns in approximately 1.7 years.

  • 5

    Semaglutide shows greater initial weight loss, but benefits diminish quickly.

  • 6

    High discontinuation rates (~50%) due to side effects or cost.

  • 7

    Long-term treatment may be necessary for sustained benefits.

  • 8

    Cost-effectiveness concerns arise for GLP-1 receptor agonists in public health systems.

Original Source(s)

Weight Regain Rapidly Follows GLP-1 Cessation

Systematic review finds most lost weight returns within two years of stopping weight management medication

  • by Conexiant News Staff

  • February 18, 2026

  • 4 min

Related Content

Intermittent Fasting Shows No Edge Over Standard Diets

Cochrane review finds the approach produces similar weight loss and quality-of-life outcomes compared with conventional calorie restriction

Berberine Evaluated for Liver Fat

Six-month randomized trial finds no reduction in visceral or hepatic fat in patients with obesity and MASLD

Oral GLP-1s Won’t Win on Convenience – They’ll Win on CMC 

GLP-1 peptides validated the science. CMC will validate the small molecule modality for GLP-1 efficacy, scalability, and access.