From the Journals

CYP2D6 Testing and Postoperative Opioids

Investigators evaluate whether genotype-guided prescribing improves postoperative pain management.

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  • 1

    Study involved 1,602 patients across 8 US health systems.

  • 2

    Focused on CYP2D6-guided opioid prescribing.

  • 3

    Improved concordance between metabolic phenotype and prescribed opioids.

  • 4

    Pain opioid use outcomes remained similar across both groups.

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    Notable shift in opioid types prescribed (e.g., hydromorphone).

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    Multimodal pain management strategies were frequently utilized.

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    Study limitations included variable adherence to guidance and missing data.

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    Conclusion indicated limited benefits of genotype-guided therapy in current practices.

Original Source(s)

CYP2D6 Testing and Postoperative Opioids

Investigators evaluate whether genotype-guided prescribing improves postoperative pain management.

  • by Kathryn Wighton

  • March 9, 2026

  • 5 min

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