When “Gluten Sensitivity” Isn’t About Gluten
November 18, 2025
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2 min
7 Key Takeaways
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1
NCGS is a condition associated with gluten consumption.
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2
About 10% of adults report symptoms of gluten sensitivity.
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3
Symptoms are inconsistent, with only 16-30% confirming in trials.
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4
FODMAPs may contribute to symptoms.
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5
Diagnosis requires exclusion of other conditions.
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6
Currently, no validated biomarkers exist for NCGS.
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7
Collaborative efforts among health professionals are necessary for improved diagnostic practices.
A recent review in The Lancet examines non-celiac gluten sensitivity (NCGS), a condition where patients experience symptoms attributed to gluten consumption despite negative celiac disease tests. Approximately 10% of adults report gluten sensitivity, yet only 16-30% exhibit consistent symptoms in clinical trials, influenced by dietary variables like FODMAPs. The absence of validated biomarkers complicates diagnosis, which currently relies on exclusion of celiac disease and wheat allergy. The authors advocate for developing new biomarkers to enhance diagnostic accuracy and underscore the need for a collaborative approach among healthcare providers.
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