From the Journals

Brain Shifts at Hidden Ages 

Manifold analysis reveals distinct organizational epochs separated by turning points at ages 9, 32, 66, and 83 years across 4,216 diffusion imaging scans.

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7 Key Takeaways

  • 1

    Key turning points: ages 9, 32, 66, 8

  • 2

    Analysis using 12 graph theory metrics.

  • 3

    Integrated data from nine diffusion imaging datasets.

  • 4

    Epochs show unique topological characteristics.

  • 5

    Importance of age-related brain maturation and decline.

  • 6

    Cross-sectional design may limit individual trajectory insights.

  • 7

    Further longitudinal studies recommended.

Original Source(s)

Brain Shifts at Hidden Ages 

Manifold analysis reveals distinct organizational epochs separated by turning points at ages 9, 32, 66, and 83 years across 4,216 diffusion imaging scans.

  • by Kerri Miller

  • November 25, 2025

  • 8 min

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