From the Journals

Rethinking Acetaminophen in the NICU

Prophylactic treatment closed the ductus arteriosus faster but did not reduce mortality or severe morbidity in extremely premature infants

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  • 1

    TREOCAPA trial involved 778 preterm infants across 43 NICUs.

  • 2

    Acetaminophen accelerated ductus arteriosus closure but did not improve survival rates.

  • 3

    Cholestasis rates were higher in acetaminophen group (6% vs 3%).

  • 4

    No significant difference in severe morbidities between groups.

  • 5

    Trial highlights the safety issues of acetaminophen use in very preterm infants.

Original Source(s)

Rethinking Acetaminophen in the NICU

Prophylactic treatment closed the ductus arteriosus faster but did not reduce mortality or severe morbidity in extremely premature infants

  • by Kerri Miller

  • February 17, 2026

  • 4 min

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