Patient Insights on HRQOL in Chronic GVHD

7 Key Takeaways

• 1

  65% of patients with cutaneous graft-vs-host disease reported dry skin, 61% reported tightness, and nearly half struggled with itchiness.

• 2

  The study identified five HRQOL domains: skin changes and symptoms, social functioning, psychological and emotional functioning, physical functioning, and general health perceptions.

• 3

  Significant gaps in patient-reported outcome measures for cutaneous chronic GVHD were identified, emphasizing the need for disease-specific tools.

• 4

  Disease duration varied significantly between the epidermal and sclerotic subtypes.

• 5

  The study cohort included 31 adults with active cutaneous chronic GVHD from the University of Pennsylvania.

• 6

  Most participants had severe disease, with sclerotic and combination subtypes more frequently classified as severe compared with epidermal cases.

• 7

  Thematic analysis revealed prevalent social impairments, psychological effects, and physical limitations.