From the Journals

Patient Insights on HRQOL in Chronic GVHD

Explore how cutaneous graft-versus-host disease impacts patients’ quality of life across physical, psychological, and social domains.

1

65% of patients with cutaneous graft-vs-host disease reported dry skin, 61% reported tightness, and nearly half struggled with itchiness.
2

The study identified five HRQOL domains: skin changes and symptoms, social functioning, psychological and emotional functioning, physical functioning, and general health perceptions.
3

Significant gaps in patient-reported outcome measures for cutaneous chronic GVHD were identified, emphasizing the need for disease-specific tools.
4

Disease duration varied significantly between the epidermal and sclerotic subtypes.
5

The study cohort included 31 adults with active cutaneous chronic GVHD from the University of Pennsylvania.
6

Most participants had severe disease, with sclerotic and combination subtypes more frequently classified as severe compared with epidermal cases.
7

Thematic analysis revealed prevalent social impairments, psychological effects, and physical limitations.