From the Journals

Psilocybin Trial in Treatment-Resistant Depression Shows Mixed Results

While primary endpoint results were negative, secondary measures showed greater reductions in depressive symptoms with high-dose psilocybin

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  • 1

    Psilocybin-assisted psychotherapy trial failed to meet primary endpoint for TRD.

  • 2

    144 adults participated after stopping existing antidepressants.

  • 3

    Significant early reduction in depressive symptoms noted with high-dose psilocybin.

  • 4

    Functional unblinding may bias results through expectancy effects.

  • 5

    Suicidal ideation higher in psilocybin 25 mg group.

  • 6

    Adverse events common; some serious responses emerged.

  • 7

    Recommendations for improved trial designs suggested.

Original Source(s)

Psilocybin Trial in Treatment-Resistant Depression Shows Mixed Results

  • by Henry Thomas

  • March 20, 2026

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