Gastric microbiome shifts track H pylori virulence
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by Kerri Miller
November 10, 2025
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2 min
8 Key Takeaways
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1
Virulent H. pylori genotypes linked to gastric microbial diversity.
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2
Study involved 66 biopsies from Indonesia.
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3
CagA polymorphisms influenced community composition.
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4
Co-colonization with taxa like Veillonella and Klebsiella noted.
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5
α-diversity was higher with virulent strains despite non-significance overall.
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6
H. pylori's dominance remains stable in gastric atrophy.
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7
Further research needed on cohabiting taxa’s role in gastric health.
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8
Study received multiple awards at ACG.
Research led by Muhammad Miftahussurur, MD, presented at the ACG 2025 Annual Scientific Meeting, reveals a connection between virulent Helicobacter pylori genotypes and increased gastric microbial diversity. Examining 66 H. pylori-positive gastric biopsies from Indonesia, the study found that while overall α-diversity was not significantly different, more virulent strains resulted in greater microbial diversity. Specific pathogenic factors influenced co-colonization with taxa such as Veillonella and Klebsiella. Findings suggest that H. pylori pathogenic factors shape gastric microbiome diversity, necessitating further investigation into these relationships and their implications for gastric pathology.
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