Trends and Challenges in Nitrosamine Testing: Part Three – Building a Method - Takeaway - MDSpire

Trends and Challenges in Nitrosamine Testing: Part Three – Building a Method

Following part two, which explored the analytical challenges involved in nitrosamine testing, our experts return to offer their top tips for building a method from scratch

  • April 24, 2026

  • 5 min

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  • 1

    Utilize LC-MS for nitrosamine analysis; GC-MS for volatile samples.

  • 2

    Identify suitable solvents for the API and impurities.

  • 3

    Optimize mass spectrometry parameters for sensitivity.

  • 4

    Validate with USP's resources and reference materials.

  • 5

    Implement solid-phase extraction when needed to enhance detection.

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Trends and Challenges in Nitrosamine Testing: Part Three – Building a Method

  • April 24, 2026