From the Journals

Zinc: Missing Link in HE Management?

Study reveals stark survival contrast: cirrhotic patients with normal zinc levels showed 86% survival rate versus significantly poorer outcomes in zinc-deficient patients (35.56 ± 11.65 mcg/dL, P<.0001), suggesting a potentially modifiable risk factor in hepatic encephalopathy management.

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  • 1

    Lower serum zinc levels were associated with higher grades of encephalopathy and more advanced cirrhosis.

  • 2

    Zinc deficiency may serve as a marker for disease progression and a potential therapeutic target.

  • 3

    Chronic alcoholism was identified as the leading cause of cirrhosis in the study.

  • 4

    Zinc level screening was recommended for all cirrhotic patients with hepatic encephalopathy.

  • 5

    The mortality rate in the study was 14% with higher mortality observed in patients with more severe grades of hepatic encephalopathy.

  • 6

    Patients with zinc deficiency had markedly lower mean serum zinc levels compared to survivors.

  • 7

    Clinical presentations varied widely, with abdominal distension, pedal edema, and icterus being the most common symptoms.

Original Source(s)

Zinc: Missing Link in HE Management?

Study reveals stark survival contrast: cirrhotic patients with normal zinc levels showed 86% survival rate versus significantly poorer outcomes in zinc-deficient patients (35.56 ± 11.65 mcg/dL, P<.0001), suggesting a potentially modifiable risk factor in hepatic encephalopathy management.

  • by Kerri Miller

  • November 7, 2024

  • 3 min

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