From the Journals

Conjugative CRISPR System Cuts Resistance

Mobile gene drive-like platform spreads between bacteria and reduces ampicillin resistance by up to 5 logs while enabling cassette reversal

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  • 1

    Engineered pPro-MobV plasmid targets antibiotic resistance.

  • 2

    Horizontal gene transfer demonstrated with a frequency of ~40%.

  • 3

    RecA-deficient strains showed enhanced effects.

  • 4

    Insertional inactivation more effective than plasmid elimination.

  • 5

    Study highlights implications for microbiome engineering and ecological health.

Original Source(s)

Conjugative CRISPR System Cuts Resistance

Mobile gene drive-like platform spreads between bacteria and reduces ampicillin resistance by up to 5 logs while enabling cassette reversal

  • by Julie Greenbaum

  • February 13, 2026

  • 4 min

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