From the Journals

How Does Trisomy 21 Affect Fetal Hematopoiesis?

Fetal hematopoietic stem cells in Down syndrome are 'primed' for differentiation, as revealed by single-cell multi-omics of over 1.1 million cells, potentially explaining early hematological abnormalities.

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5 Key Takeaways

  • 1

    Down syndrome fetuses show alterations in hematopoietic stem cells, indicative of prenatal changes.

  • 2

    Dysregulation of hematopoiesis may impact leukemia risk in Down syndrome.

  • 3

    Trisomy enhances accessibility and gene upregulation in hematopoietic stem cells.

  • 4

    Down syndrome hematopoietic stem cells exhibit increased mitochondrial mass and oxidative stress.

  • 5

    Study links dysregulation of gene expression to trisomy, potentially influencing erythroid lineage differentiation and leukemia risk.

Original Source(s)

How Does Trisomy 21 Affect Fetal Hematopoiesis?

Fetal hematopoietic stem cells in Down syndrome are 'primed' for differentiation, as revealed by single-cell multi-omics of over 1.1 million cells, potentially explaining early hematological abnormalities.

  • by Kathryn Wighton

  • October 4, 2024

  • 3 min

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