Bundled Care Strategy May Reduce Moderate to Severe AKI - Takeaway - MDSpire
From the Journals

Bundled Care Strategy May Reduce Moderate to Severe AKI

Multicenter trial finds KDIGO-recommended approach lowers moderate to severe acute kidney injury; measured 90-day outcomes were similar between groups

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  • 1

    The BigpAK-2 trial focused on preventing acute kidney injury (AKI) in high-risk surgical patients.

  • 2

    A KDIGO-based strategy reduced moderate to severe AKI from 22% to 14%.

  • 3

    Key interventions involved hemodynamic optimization and avoiding nephrotoxins.

  • 4

    Adherence to the strategy was higher without strict glycemic control.

  • 5

    Subgroup analyses showed consistent outcomes across various surgical types and demographics.

Original Source(s)

Bundled Care Strategy May Reduce Moderate to Severe AKI

  • by Kathryn Wighton

  • April 17, 2026

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