Distinct Monocyte State Linked to Fatigue and Pulmonary Impairment in Long COVID
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By
February 4, 2026
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3 min
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1
Distinct immune cell state linked to long COVID was identified as LC-Mo.
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2
Elevated levels of CCL2 and CXCL11 cytokines persist for up to 9 months post infection.
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3
Higher LC-Mo levels correlate with increased fatigue and poorer respiratory outcomes.
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4
Continued immune activation is suggested by elevated cytokine levels.
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5
Findings emphasize a link between immune alterations and lung remodeling, needing further study on causality.
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A recent study has identified a specific immune cell state linked to chronic fatigue and respiratory issues in long COVID patients. Researchers discovered a CD14-positive monocyte transcriptional state, termed LC-Mo, associated with systemic immune dysfunction and ongoing inflammation lasting up to nine months post SARS-CoV-2 infection. Patients exhibiting higher LC-Mo levels showed greater fatigue and poorer respiratory outcomes, suggesting a potential link between immune alterations and lung remodeling. While these associations are evident, further research is needed to confirm causality and explore therapeutic options.
-
1
Distinct immune cell state linked to long COVID was identified as LC-Mo.
-
2
Elevated levels of CCL2 and CXCL11 cytokines persist for up to 9 months post infection.
-
3
Higher LC-Mo levels correlate with increased fatigue and poorer respiratory outcomes.
-
4
Continued immune activation is suggested by elevated cytokine levels.
-
5
Findings emphasize a link between immune alterations and lung remodeling, needing further study on causality.
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