From the Journals

DIM Supplement Alters Estradiol Patch Metabolism

A retrospective study found that DIM supplements significantly changed estrogen metabolism in postmenopausal women using estradiol patches, suggesting a potential drug-supplement interaction that may affect hormone therapy outcomes.

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  • 1

    DIM is derived from cruciferous vegetables.

  • 2

    Study included 1,458 postmenopausal women.

  • 3

    Significant estrogen profile differences were observed between DIM users and non-users.

  • 4

    DIM may induce cytochrome P450 enzymes, affecting hormone metabolism.

  • 5

    Importance of healthcare providers discussing supplement use with patients on MHT.

  • 6

    Future research needed to assess effects on therapeutic outcomes.

Original Source(s)

DIM Supplement Alters Estradiol Patch Metabolism

A retrospective study found that DIM supplements significantly changed estrogen metabolism in postmenopausal women using estradiol patches, suggesting a potential drug-supplement interaction that may affect hormone therapy outcomes.

  • by Stanley Gajete

  • July 16, 2025

  • 3 min

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