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IL-31 and IL-33 are cytokines linked to itch in atopic dermatitis.
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Atopic dermatitis is characterized by dry skin and itchy lesions.
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IL-33 acts as an alarmin released during skin injury.
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IL-31 directly stimulates itch-sensing nerve fibers.
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Increased IL-31 and IL-33 correlate with disease severity, aiding treatment monitoring.
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The interaction between immune molecules IL-31 and IL-33 is pivotal in driving the intense itching associated with atopic dermatitis, a chronic inflammatory skin condition characterized by a compromised barrier and recurrent eczema-like lesions. This cytokine axis creates a feedback loop linking immune activation to nerve signaling, exacerbating itching when the skin barrier is compromised. Elevated levels of IL-31 and IL-33 correlate with disease severity, providing insights into potential targets for new treatments and helping clinicians monitor therapeutic responses.
-
1
IL-31 and IL-33 are cytokines linked to itch in atopic dermatitis.
-
2
Atopic dermatitis is characterized by dry skin and itchy lesions.
-
3
IL-33 acts as an alarmin released during skin injury.
-
4
IL-31 directly stimulates itch-sensing nerve fibers.
-
5
Increased IL-31 and IL-33 correlate with disease severity, aiding treatment monitoring.
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