From the Journals

Delgocitinib Cream Outperforms Alitretinoin in Trial

Topical delgocitinib improved eczema severity scores and caused fewer adverse events than oral alitretinoin in adults with severe chronic hand eczema, according to a phase 3 study.

by Stanley Gajete
April 28, 2025
3 min

Conexiant

1

Delgocitinib cream was more effective and safer than oral alitretinoin in treating severe chronic hand eczema.
2

Delgocitinib showed a significantly greater reduction in Hand Eczema Severity Index scores at week 1
3

More patients in the delgocitinib group achieved at least a 90% improvement in HECSI scores.
4

Delgocitinib provided greater relief from itch and pain compared to alitretinoin.
5

Delgocitinib is a nonsteroidal topical pan–Janus kinase (JAK) inhibitor targeting multiple inflammatory pathways.
6

The study supports delgocitinib cream as a potential nonsystemic treatment alternative for severe chronic hand eczema.