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Commentary & Perspectives

Prednisolone Linked to Metabolic Benefits

A randomized crossover trial found slower bone turnover and no safety differences compared with standard hydrocortisone regimens

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    Low-dose prednisolone may have cardiometabolic benefits over hydrocortisone.

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    Study involved 46 patients with adrenal insufficiency.

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    Prednisolone dosage ranged from 2 to 5 mg.

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    Slower bone turnover observed with prednisolone.

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    Improvements noted in weight and diabetes markers.

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    Subjective health outcomes were similar between treatments.

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    No adrenal crises reported.

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    Longer-term studies are required for clinical significance.

Original Source(s)

Prednisolone Linked to Metabolic Benefits

  • by Henry Thomas

  • April 1, 2026

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