Clinical Guidelines

Mass Spectrometry Takes on Amyloid 

New guidelines target false negatives, Congo red variability, and the growing role of mass spectrometry in amyloid typing

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  • February 18, 2026

  • 9 min

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  • 1

    CAP guidelines standardize amyloid diagnostics.

  • 2

    Mass spectrometry is the recommended method for fibril typing.

  • 3

    Congo red staining methods need optimization.

  • 4

    Fat pad FNA offers minimal invasiveness with variable sensitivity.

  • 5

    Standardized tissue section thickness is critical.

  • 6

    Emerging technologies like infrared spectroscopy show promise.

  • 7

    Accurate fibril typing is essential for targeted therapy.

Original Source(s)

Mass Spectrometry Takes on Amyloid 

New guidelines target false negatives, Congo red variability, and the growing role of mass spectrometry in amyloid typing

  • February 18, 2026

  • 9 min

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