Feature

Refining Single-Cell Metabolomics with Ion Mobility

Ion mobility-resolved mass cytometry expands metabolite coverage across thousands of single cells 

  • By

  • February 24, 2026

  • 2 min

Share

  • 1

    Workflow combines ion mobility separation with mass cytometry.

  • 2

    Addresses challenges in single-cell metabolomics.

  • 3

    Uses 'cell superposition' for improved detection.

  • 4

    Introduces the MetCell computational workflow.

  • 5

    Analyzed over 45,000 liver cells.

  • 6

    Revealed metabolic variations in aging.

  • 7

    Applicable to various ion mobility-based platforms.

Original Source(s)

Refining Single-Cell Metabolomics with Ion Mobility

Ion mobility-resolved mass cytometry expands metabolite coverage across thousands of single cells 

  • February 24, 2026

  • 2 min

Related Content

Tracing Metabolic Inflexibility in Fanconi Anemia 

Stable-isotope glucose tracing reveals impaired fuel switching and altered energy use in a rare DNA-repair disorder 

FDA Approves First Once-Daily Oral Therapy for Acromegaly

Once-daily paltusotine offers an oral alternative to monthly injections for eligible adults.

Protein Powerhouse

Sitting Down With... Ruedi Aebersold, Deputy Head, Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland.