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From the Journals

The Hidden Differences Between Oral Contraceptives

National adverse-event and prescribing data suggest oral contraceptive formulations differ in reported acne, migraine, anxiety, and depression 

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  • 1

    Formulations differ in side effects like acne, migraine, anxiety, and depression.

  • 2

    Drospirenone linked to higher migraine and depression rates.

  • 3

    Levonorgestrel associated with increased anxiety reports.

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    Study period: 2016-

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    Limitations include lack of clinical detail.

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    Oral contraceptives well tolerated but side effects common.

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    Tailoring contraceptive choices may benefit patients with comorbidities.

  • 8

    No conflicts of interest reported by authors.

Original Source(s)

The Hidden Differences Between Oral Contraceptives

  • by Henry Thomas

  • March 26, 2026

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