Medical Oddities: When Body Fat Gets to Your Head
-
By
January 28, 2026
-
5 min
-
1
Study involved 26,000 UK Biobank participants using MRI.
-
2
Identified six fat distribution patterns.
-
3
Pancreatic-predominant and 'skinny-fat' patterns linked to brain health issues.
-
4
Smaller brain volumes noted in relation to fat patterns.
-
5
Increased prevalence of mood disorders and cognitive impairments with high-risk fat distributions.
-
Research using whole-body MRI on nearly 26,000 UK Biobank participants reveals that the location of body fat significantly impacts brain health. It identifies six distinct fat distribution patterns, notably the pancreatic-predominant and 'skinny-fat' patterns, which correlate with decreased brain volumes, increased white matter lesions, and impaired cognitive abilities. These patterns also show a higher risk of neurologic disorders including mood issues and strokes. This suggests that the spatial distribution of fat is more critical for neurologic health than weight alone.
-
1
Study involved 26,000 UK Biobank participants using MRI.
-
2
Identified six fat distribution patterns.
-
3
Pancreatic-predominant and 'skinny-fat' patterns linked to brain health issues.
-
4
Smaller brain volumes noted in relation to fat patterns.
-
5
Increased prevalence of mood disorders and cognitive impairments with high-risk fat distributions.
Listen Tab content