From the Journals

Sickle Cell Stroke Rates Rise Post-STOP

Despite STOP trial interventions, ischemic stroke rates for children in California with sickle cell disease increased by 42% from 1999-2009 to 2010-2019, a large population-based study reveals.

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  • 1

    Ischemic stroke rates in Californians with sickle cell disease have increased significantly, particularly in children and adults.

  • 2

    Risk factors for ischemic stroke include hypertension, hyperlipidemia, and prior cerebrovascular disorders.

  • 3

    The study utilized the Health Care Access and Innovation database and demonstrated a rising trend in stroke rates across all age groups since the STOP trial.

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    Comorbidities such as acute chest syndrome and renal failure were prevalent among affected individuals.

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    The study identified several limitations, including a lack of data on silent cerebral infarction, potential underestimation of events, and evolving definitions of TIA versus ischemic stroke.

Original Source(s)

Sickle Cell Stroke Rates Rise Post-STOP

Despite STOP trial interventions, ischemic stroke rates for children in California with sickle cell disease increased by 42% from 1999-2009 to 2010-2019, a large population-based study reveals.

  • by Kerri Miller

  • September 23, 2024

  • 5 min

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