Commentary & Perspectives

Earlier Detection of Organ Rejection

CAP review outlines how donor-derived DNA assays can support earlier, less invasive detection of graft injury

  • By

  • February 27, 2026

  • 2 min

Share

  • 1

    dd-cfDNA testing enables early detection of graft injury.

  • 2

    Low levels of dd-cfDNA indicate stable graft health.

  • 3

    Two detection methods: next-gen sequencing and droplet digital PCR.

  • 4

    Clinical applications are strongest in kidney and heart transplants.

  • 5

    Rising dd-cfDNA levels may signal acute rejection.

  • 6

    Testing can reduce unnecessary biopsies.

  • 7

    Emerging applications in liver and lung transplants.

  • 8

    Molecular monitoring may reshape transplant diagnostics.

Original Source(s)

Earlier Detection of Organ Rejection

CAP review outlines how donor-derived DNA assays can support earlier, less invasive detection of graft injury

  • February 27, 2026

  • 2 min

Related Content

Unexpected Diagnosis in Ring Finger Mass

Histopathology reveals digital actinomycosis in a young patient.

What Shapes Pediatric Platelet Response?

REDS-IV-P data examine how storage time, pathogen reduction, and donor factors affect transfusion outcomes in pediatric patients

From Genome to Multi-ome

Why scientists should rethink rare disease investigation methods