From the Journals

Topical 5-FU as First-Line Bowen’s Therapy

Selecting treatment for Bowen’s disease: where topical 5-fluorouracil fits

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7 Key Takeaways

  • 1

    Bowen's disease treatment requires balancing clearance, burden, and patient preferences.

  • 2

    A study in Dermatology assessed topical 5-FU for 250 patients.

  • 3

    Surgical excision showed the highest sustained clearance at 12 months.

  • 4

    Topical 5-FU is effective with a reduced treatment burden.

  • 5

    Lower intensity and convenience make 5-FU suitable for older patients.

  • 6

    Recurrences after 5-FU are manageable.

  • 7

    Treatment decisions should consider patient-centered care.

Original Source(s)

Topical 5-FU as First-Line Bowen’s Therapy

Selecting treatment for Bowen’s disease: where topical 5-fluorouracil fits

  • by Alun Evans

  • January 13, 2026

  • 2 min

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