Clinical Guidelines

The 60 Percent Diagnostic Gap in M/E

What earlier mNGS testing could mean for labs and clinicians

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  • 1

    Meningitis/encephalitis often have undetermined causes despite testing.

  • 2

    mNGS can aid in diagnostics by identifying pathogens earlier.

  • 3

    Over 60% of M/E cases can remain undiagnosed with standard methods.

  • 4

    Early mNGS testing reduces time to diagnosis significantly.

  • 5

    Interpretation of mNGS results needs close clinical collaboration.

  • 6

    Antimicrobial stewardship can be improved with mNGS guidance.

  • 7

    Integration of mNGS requires validated performance and clinician education.

Original Source(s)

The 60 Percent Diagnostic Gap in M/E

What earlier mNGS testing could mean for labs and clinicians

  • by Jessica Allerton

  • March 12, 2026

  • 6 min

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