Apocrine Gland Changes in Early Hidradenitis Suppurativa
November 18, 2024
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2 min
8 Key Takeaways
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1
Study in the Journal of Investigative Dermatology identifies apocrine gland damage and keratin release in HS pathogenesis.
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2
Significant reduction in apocrine gland size observed in LS and NLS compared with healthy controls.
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3
Histologic analysis showed severe degeneration in LS and NLS apocrine glands.
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4
Elevated levels of keratins KRT18 and KRT19 observed in patients with HS.
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5
AG dysfunction and keratin release may contribute to early inflammatory processes in HS.
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6
Potential biomarkers for HS severity and progression.
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7
Associations between serum KRT19 levels and age at disease onset.
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8
Further research needed to validate the clinical utility of identified biomarkers.
A recent study published in the Journal of Investigative Dermatology has identified apocrine gland damage and the release of specific keratins, KRT18 and KRT19, as potential factors in the early pathogenesis of hidradenitis suppurativa (HS). The study analyzed skin samples from patients with HS and healthy controls, revealing significant reduction in apocrine gland size, cellular degeneration, and elevated levels of keratins in HS patients. These findings suggest a potential role for apocrine gland dysfunction and keratin release in early inflammatory processes in HS, highlighting the need for further research to validate their clinical utility as potential biomarkers for HS severity and progression. The study also indicated potential associations between serum KRT19 levels and age at disease onset, signaling the need for further investigation into its role in early disease detection.
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